The resultant bone lesions are lytic (cause breakdown) in nature, and are best seen in plain radiographs, which may show punched-out resorptive lesions (including the raindrop appearance of the skull on radiography).The genetic and epigenetic changes just described occur in a step-wise fashion.The 11q13 and 6p21 cytogenetic abnormalities are associated with a better prognosis. It usually occurs around the age of 61 and is more common in men than women. In rare cases the globulin elevation is Ig M, which is referred to as Waldenström s macroglobulinemia.
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Patients without evidence of a monoclonal protein may have nonsecretory myeloma (not producing immunoglobulins); this represents approximately 3% of all multiple myeloma patients.
[ Initial therapy Initial treatment of multiple myeloma depends on the patient’s age and comorbidities.
It is not curative, but does prolong overall survival and complete remission.
United States In the United States in 2016, there will be an estimated 30,330 new cases and 12,650 deaths.
Persistent localized pain may indicate a pathological bone fracture.